BACKGROUNDPeriodic spacing of brief adenine or thymine runs phased with DNA helical interval of ~10.5 bp is related to intrinsic DNA curvature and deformability, which play essential roles in DNA-protein interactions and in the group of chromosomes in each eukaryotes and prokaryotes.
Local variations in DNA sequence periodicity have been linked to variations in gene expression in some organisms. Despite the importance of these periodic patterns, there are nearly no publicly accessible tools for their analysis.RESULTSWe current novel tools appropriate for assessments of DNA curvature-related sequence periodicity in nucleotide sequences on the genome scale.
Utility of the current software program is demonstrated on a comparability of sequence periodicities in the genomes of Haemophilus influenzae, Methanocaldococcus jannaschii, Saccharomyces cerevisiae, and Arabidopsis thaliana.
The software program may be accessed by an internet interface and the applications are additionally accessible for obtain.CONCLUSIONSThe current software program is appropriate for evaluating DNA curvature-related sequence periodicity amongst completely different genomes in addition to for analysis of intrachromosomal heterogeneity of the sequence periodicity.
It offers a fast and handy approach to detect anomalous areas of chromosomes that would have uncommon structural and practical properties and/or distinct evolutionary historical past.
DNAlive: a software for the bodily analysis of DNA on the genomic scale.
CONCLUSIONSDNAlive is a software for the analysis and graphical show of structural and bodily traits of genomic DNA. The internet server implements a large repertoire of metrics to derive bodily info from DNA sequences with a strong interface to derive 3D info on giant sequences of each bare and protein-bound DNAs.
Furthermore, it implements a mesoscopic Metropolis code which permits the cheap research of the dynamic properties of chromatin fibers. In addition, our server additionally surveys different protein and genomic databases permitting the consumer to mix and discover the bodily properties of chosen DNA in the context of practical options annotated on these areas.